1、单击此处编辑母版标题样式单击此处编辑母版副标题样式* 1Bacillary Dysentery (shigellosis) DefinitionAcute infectious disease of intestine caused by dysentery bacilli(genus shigella)Place of lesion: sigmoid & rectumPathological feature: diffuse fibrious exudative inflammationDefinitionClinical manifestation: fever, abdominal pa
2、in, diarrhea, tenesmus , stool mixed with mucus blood, & pus. even companied with shock, toxic-encepholopthy.EtiologyCausative organism: dysentery bacilli, genus shigella, gram-stained negative, non-motile short rod, Groups: 4 serogroups &47 serotypesEtiologyS. dysenteriae: the most severeS. flexner
3、i: the epidemic group and easily turn to chronicS. boydii: tropical and subonS. sonnei: the most mildEtiologyPathogenicity:- virulenceendotoxin - exotoxin- invasiveness(attach-penetrate-multiply) Resistance: Strong, 1-2week in fruits,vegetable and dirty soil, heat for 60 30 minEpidemiologySource of
4、infection:patients and carriersRoute of transmission: fecal-oral routeSuceptibility of population:immunity after infection is short and unsteady, no cross-immuneEpidemiologyEpidemic features:season: summer & fallFlexneri, Soneii, dysenteryage: younger childrenPathogenesisnumber of bacteriatoxicityin
5、vasivenessattachmentpenetrationmultiplicationimmunitycommonBacteriaintestinenormal intestinal florasIg A prevent attachingpenetrate mucusmultiply in epithelia cell & proper laminaendotoxinendogenous pyrogen feverinflammationvessel contractionsuperficial mucosal necrosis and ulcerdiarrhea mixed with blood & pus, abdominal pain
